Stem Cell Therapy for Rheumatoid Arthritis in Mexico
- Designed for systemic immune modulation
- Expert-led protocols for autoimmune disease
- Advanced therapeutic option for biologic-refractory RA
- 4.7-star Google rating
- HIPAA-secure
- Patients from 12 + countries
When Your Rheumatoid Arthritis Treatment Is No Longer Enough
Living with rheumatoid arthritis is not only about pain. It is the constant worry about what comes next: the risk of progressive joint damage, losing independence and needing help for simple tasks while your world feels smaller.
• Morning stiffness that makes getting out of bed a negotiation.
• Deep, systemic fatigue that no amount of sleep seems to fix.
• Unpredictable flares that derail your plans without warning.
• Brain fog that makes it hard to focus and feel like yourself.
• Ongoing side effects or anxiety about years on methotrexate or biologics.
This is what refractory RA can look like: a systemic immune disease that remains active despite standard DMARDs or biologics. At this point, the goal is no longer just “less pain”, but finding a safer, more sustainable way to regain meaningful control over the course of the disease.
Clinical Goals of Our Stem Cell Protocol for Rheumatoid Arthritis
Lower inflammatory blood markers
Helps reduce key markers such as CRP and ESR, which rheumatologists use to monitor rheumatoid arthritis activity over time.
Improved disease activity scores (DAS28, CDAI)
Designed to achieve better results on standardized rheumatology scores that reflect how active your Rheumatoid Arthritis is over time.
Reduced daily symptom burden
Seeks to lessen the impact of debilitating morning stiffness, systemic fatigue and “brain fog” so daily activities feel more manageable.
Fewer and less intense flares
Aims to decrease the frequency and severity of inflammatory flares, helping your disease course feel more predictable and controlled.
Better joint function and mobility
Aims to decrease the frequency and severity of inflammatory flares, helping your disease course feel more predictable and controlled.
An option for refractory or biologic-experienced RA
Provides an advanced therapeutic pathway for patients who have not achieved adequate, sustainable control with conventional DMARDs or biologic therapies, and who need a different type of immune-focused strategy.
Our 4-Step Protocol: A Medical System, Not a Single Injection
Step 1. Comprehensive Clinical Evaluation and Candidacy Assessment
Everything begins with a complete medical evaluation. Your case is reviewed by our clinical team with special attention to:
Your confirmed diagnosis of Rheumatoid Arthritis and the length of time you have lived with the disease.
Your previous and current treatments (DMARDs, biologics, and other medications).
Comorbidities, organ function, metabolic status, and functional capacity in daily life.
To establish a baseline, we review key inflammatory markers (such as C-reactive protein [CRP] and erythrocyte sedimentation rate [ESR]) and use disease activity scores (for example, DAS28), in addition to your predominant symptoms (morning stiffness, fatigue, pain, functional limitation).
Our protocol is designed to complement, not replace, your current care plan. Whenever possible, we encourage coordination with your primary rheumatologist so that the decisions made here are aligned with your overall therapeutic strategy.
This first step allows us to understand both your autoimmune activity and your general “biological terrain,” so that any regenerative intervention is adapted to your real clinical context and not applied as a generic protocol.
Step 2. In-House COFEPRIS-Licensed Laboratory – Fresh Clinical-Grade Cells
A central part of your treatment is the quality and origin of the cellular product you receive.
Your therapeutic cell preparation is produced in our own COFEPRIS-licensed laboratory. For this protocol, we do not depend on pre-frozen (cryopreserved) products purchased from external banks. Instead, your mesenchymal stem cell (MSC) preparation is produced fresh for clinical use, following standardized procedures designed to maximize viability, integrity, and functional performance.
Each dose undergoes multi-step quality control before being released for treatment, including:
Verification of identity and cell count.
Viability testing.
Sterility and safety checks.
This internal, traceable, regulated process ensures that what you receive is consistent and documented, and aligned with strict medical and regulatory standards.
Step 3. Integrated Treatment Phase – Systemic, Multimodal Approach
Rheumatoid Arthritis is a systemic immune disease, which is why our therapeutic strategy begins at the systemic level. Your protocol is multimodal: we combine several therapeutic layers, tailored to your specific case, to support immune modulation, decrease inflammatory burden, and optimize your biological terrain.
Typical components of your protocol may include:
1. Core regenerative therapy (systemic IV)
The central element is your intravenous (IV) infusion of fresh mesenchymal stem cells. This therapy is designed to circulate through the bloodstream, reach inflamed tissues, and support systemic immune modulation, rather than focusing solely on a single joint.
2. Plasmapheresis and biological terrain support therapies
To create a more favorable internal environment for regeneration, in selected cases we may integrate:
Nanomembrane plasmapheresis, designed to reduce certain undesirable components in the blood (such as circulating autoantibodies and inflammatory mediators) and ease the load on the immune system.
Intravenous nutrient infusions, aimed at correcting key deficiencies and supporting cellular metabolism.
Ozone therapy, with the goal of improving tissue oxygenation and modulating oxidative stress.
Exosome-based therapies, focused on cellular signaling and communication.
Not all patients receive all of these modalities. Each element is indicated case by case, according to your clinical evaluation, your risk profile, and your therapeutic goals.
3. Targeted joint support (when necessary)
In cases where one or two “dominant” joints show severe local damage or particularly limiting symptoms (for example, knees or wrists), the physician may recommend a complementary intra-articular (IA) intervention.
This allows a concentrated dose of regenerative support to be delivered directly to the areas that most restrict your movement and daily function, while the systemic component acts on the underlying autoimmune process.
This integrated, physician-led approach is designed to treat your systemic immune condition and, at the same time, address the joints that most affect your quality of life — not simply chase pain in a single isolated area.
Step 4. Structured Follow-Up and Objective Outcome Monitoring
Our relationship with you continues after you leave the clinic.
We establish a clear follow-up plan to evaluate your progress over time. Whenever possible, we use the same objective criteria we measured in Step 1, such as:
Disease activity scores (for example, DAS28).
Inflammatory blood markers (CRP, ESR).
Changes you report in fatigue, morning stiffness, pain levels, and functional capacity in your daily activities.
By combining how you feel with structured clinical measurements, we can assess your response more objectively and make informed decisions about adjustments, reinforcements, or additional supportive interventions when needed.
Treatment parameters—dose, frequency, sequence, route and site of administration—and any adjunctive therapies are individualized following a comprehensive clinical evaluation and aligned with your objectives. We do not offer standardized treatment packages.
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Expert-guided, lab-developed, patient-centered: our immunotherapy is built around you.
Frequently Asked Questions About Stem Cell Therapy for Rheumatoid Arthritis in Mexico
What type of stem cells do you use for rheumatoid arthritis, and how do you ensure they are safe?
For our rheumatoid arthritis stem cell treatment, we use clinical-grade, fresh (non-cryopreserved) mesenchymal stem cells (MSCs) derived from donated umbilical cord tissue, specifically Wharton’s Jelly. This source is ethically obtained and provides an immune-privileged cell type. This means these cells are not recognized as “foreign” by your body’s immune system and do not require HLA donor matching, which is why they can be used safely in this allogeneic (donor) context.
All cell preparations are produced in our in-house, COFEPRIS-licensed laboratory (the federal health authority in Mexico). Each batch goes through strict quality control before it is released for clinical use, including:
Cell identity and cell-count verification
Viability testing
Sterility and safety checks
This process is designed to ensure that the stem cells used in your rheumatoid arthritis treatment are consistent, traceable and of high quality.
How much does stem cell therapy for rheumatoid arthritis cost in Mexico?
The cost of stem cell therapy for rheumatoid arthritis in Mexico varies widely between clinics and depends on what is actually included in the protocol.
In our case, the price reflects a comprehensive medical program, not a single injection. Your investment covers:
A personalized, multimodal protocol (as described in our 4-step system)
The full laboratory work required to prepare fresh, high-viability MSCs
The central regenerative IV infusion
Additional supportive therapies that may be indicated in your case, such as nanomembrane plasmapheresis, IV nutrient infusions, ozone therapy or exosome-based therapies
After your free medical assessment, we provide a clear, all-inclusive cost breakdown based on your clinical needs. Our goal is to offer high medical value and measurable outcomes, not to compete as the cheapest option among stem cell clinics in Mexico.
Does stem cell therapy really work for rheumatoid arthritis, and how do you measure success?
When asking “Does stem cell therapy work for rheumatoid arthritis?”, it is important to define the goal. This treatment is not presented as a cure. The objective is systemic immune modulation — to help:
Reduce chronic inflammation
Decrease the burden of symptoms such as fatigue, morning stiffness and flares
Improve overall function and quality of life
We measure success using the same type of tools your rheumatologist uses, not only “how you feel.” Whenever possible, we track:
Changes in disease activity scores, such as DAS28
Trends in inflammatory blood markers, like CRP and ESR
Your reported changes in daily function, pain levels, fatigue and morning stiffness
In other words, our stem cell therapy for rheumatoid arthritis is evaluated through both subjective improvement and objective clinical data over time.
Am I a candidate for this treatment? Do I have to stop my biologics (like Humira or Enbrel)?
Ideal candidates for our rheumatoid arthritis stem cell treatment in Mexico are usually patients with active RA who have had an inadequate response or intolerance to conventional treatments such as DMARDs and/or biologics — often referred to as refractory RA.
Regarding your current medications (such as methotrexate, Humira, Enbrel or similar agents):
You do not automatically have to stop them.
Any adjustment is a medical decision, made case by case, ideally in coordination with your primary rheumatologist.
In many situations, our protocol is designed as an integrative or complementary approach — an alternative rheumatoid arthritis treatment pathway that aims to work alongside your existing plan, not against it. Your eligibility and any medication changes are discussed in detail during your medical assessment.
Is stem cell therapy in Mexico safe? What side effects should I expect?
When patients ask “Is stem cell therapy in Mexico safe?”, they are usually concerned about both the clinic and the product itself.
From a product standpoint, clinical studies of clinical-grade MSC therapy for inflammatory and autoimmune conditions have generally reported a favorable safety profile.
In our protocol, the most commonly reported side effects of IV stem cell therapy for arthritis are usually mild and transient, and may include:
Low-grade fever
Headache
Temporary fatigue or flu-like symptoms in the first 24–48 hours
As with any medical procedure, there are potential risks, which are carefully reviewed with you during the consent process. Your individual risk profile is evaluated in detail before you are accepted as a candidate.
How long does stem cell therapy for rheumatoid arthritis in Mexico take, and what happens after I go home?
Our stem cell therapy program for rheumatoid arthritis in Mexico is a multi-day medical process, not a single appointment.
The main infusions and core interventions are usually completed over several consecutive days.
Depending on your case and whether therapies such as plasmapheresis, IV nutrients or ozone therapy are indicated, most patients should plan for a stay of approximately 7 to 15 days.
After you return home, our medical team provides structured follow-up, as outlined in our 4-step protocol. Whenever possible, we:
Review your lab results and disease activity scores (such as DAS28, CRP and ESR) over time
Monitor changes in your symptoms and functional capacity
Coordinate with your local rheumatologist when needed
This combination of on-site treatment in Mexico and remote follow-up is designed to ensure that stem cell therapy for rheumatoid arthritis is not just a one-time event, but a monitored process with clear clinical goals.