Edelmiro Santiago Osorio, Ph.D.

Edelmiro Santiago Osorio, Ph.D.

Specialty: Hematopoiesis and leukemia; mesenchymal stem cells; nutraceuticals (sodium caseinate, Sechium edule); oxidative stress & aging; translational periodontics and metabolic health

Dr. Edelmiro Santiago Osorio is a biomedical scientist focused on hematopoiesis, leukemia biology, and translational strategies that bridge nutraceuticals and cell therapy. His work spans preclinical leukemia models, clinical and geroscience studies in older adults with metabolic syndrome, and dental pulp mesenchymal stem cells applied to periodontal regeneration. He is part of IRM’s Scientific Team and has contributed to peer-reviewed studies, patents, and the training of graduate researchers.

SNI: National Researcher (SNI) Level II, 2014–2022

Areas of Focus

  • Hematopoietic regulation and leukemia (in vitro and in vivo)
  • Mesenchymal stem cells (dental pulp) and tissue regeneration
  • Nutraceuticals/functional foods (Sechium edule, casein/caseinate) for redox and inflammatory modulation
  • Metabolic syndrome, telomere biology, and aging markers
  • Chemoresistance mechanisms and combination therapies (e.g., sodium caseinate + anthracyclines/ara-C)

Education

  • Ph.D. in Biological Sciences — Universidad Nacional Autónoma de México (UNAM), 1996
  • M.Sc. in Biological Sciences — UNAM, 1990
  • B.Sc. in Biology — UNAM, 1987

Patents (selected)

  • Fatty acid amides derived from piperazine and 2,5-diazabicyclo[2.2.1]heptane with antineoplastic activity. IMPI patent no. 340157 (2016)
  • Plant compositions including Sechium chinantlense and Sechium compositum extracts for antineoplastic use. IMPI patent no. 348744 (2017)
  • Use of sodium caseinate as an antineoplastic agent. IMPI patent no. 50465 (2017)

Highlighted Scientific Publications

  • García-Martínez B.I., Ruiz-Ramos M., Pedraza-Chaverri J., Santiago-Osorio E., Mendoza-Núñez V.M. Influence of age and dose on the effect of resveratrol for glycemic control in type 2 diabetes mellitus: Systematic review and meta-analysis. Molecules 27:5232 (2022). doi:10.3390/molecules27165232
  • Aguiñiga-Sánchez I., Ledesma-Martínez E., Lara-Castañeda J.L., Meléndez-Ibarra F., Weiss-Steider B., Soto-Cruz I., Fajardo-Orduña G., Santiago-Osorio E. Sodium caseinate in combination with daunorubicin or cytarabine improves survival of mice with long-established leukemia. Cancer Diagnosis & Prognosis 2(4):496–502 (2022). doi:10.21873/cdp.10133
  • Arista-Ugalde T.L., Santiago-Osorio E., Monroy-García A., Mendoza-Núñez V.M., Rosado-Pérez J., Aguiñiga-Sánchez I., Cadena-Íñiguez J., Gavia-García G. Antioxidant and anti-inflammatory effect of powdered Sechium edule var. nigrum spinosum in Mexican older adults with metabolic syndrome. Antioxidants 11(6):1076 (2022). doi:10.3390/antiox11061076
  • Cadena-Íñiguez J., Aguiñiga-Sánchez I., Uriostegui-Arias M.T., Santiago-Osorio E., Ruiz-Posadas L.M., Soto-Hernández M. Antiproliferative effect of Sechium edule cv. Madre Negra extracts on breast cancer in vitro. Separations 9(9):230 (2022)
  • García-Martínez B.I., Ruiz-Ramos M., Pedraza-Chaverri J., Santiago-Osorio E., Mendoza-Núñez V.M. Hypoglycemic effect of resveratrol: Systematic review and meta-analysis. Antioxidants 10(1):69 (2021). doi:10.3390/antiox10010069
  • Aguiñiga-Sánchez I., Meléndez-Ibarra F.M., Ledesma-Martínez E., Weiss-Steider B., Fajardo-Orduña G.R., Rangel-Corona R., Santiago-Osorio E. Improved survival of leukemic mice treated with sodium caseinate in combination with daunorubicin without toxicity. Journal of Oncology Article ID 6635650 (2021). doi:10.1155/2021/6635650
  • Gavia-García G., Rosado-Pérez J., Arista-Ugalde T.L., Aguiñiga-Sánchez I., Santiago-Osorio E., Mendoza-Núñez V.M. Telomere length, oxidative stress and relationship with metabolic-syndrome components in aging. Biology 10(4):253 (2021). doi:10.3390/biology10040253
  • Fajardo-Orduña G.R., Ledesma-Martínez E., Aguiñiga-Sánchez I., Mora-García M.L., Weiss-Steider B., Santiago-Osorio E. Inhibitors of chemoresistance pathways with Ara-C to overcome multidrug resistance in AML: Mini-review. International Journal of Molecular Sciences 22:4955 (2021). doi:10.3390/ijms22094955
  • Aguiñiga-Sánchez I., Soto-Hernández M., Cadena-Íñiguez J., Suwalsky M., Colina J.R., Castillo I., Santiago-Osorio E. Phytochemical analysis and antioxidant/anti-inflammatory capacity of Sechium hybrid fruit extracts. Molecules 25(20):4637 (2020). doi:10.3390/molecules25204637
  • Hernández-Monjaraz B., Santiago-Osorio E., Ledesma-Martínez E., Aguiñiga-Sánchez I., Sosa-Hernández N.A., Mendoza-Núñez V.M. Dental pulp mesenchymal stem cells as a treatment for periodontal disease in older adults. Stem Cells International Article ID 8890873 (2020). doi:10.1155/2020/8890873
  • Gavia-García G., Rosado-Pérez J., Aguiñiga-Sánchez I., Santiago-Osorio E., Mendoza-Núñez V.M. Effect of Sechium edule var. nigrum spinosum on telomerase levels and antioxidant capacity in older adults with metabolic syndrome. Antioxidants 9(7):634 (2020). doi:10.3390/antiox9070634
  • Mendoza-Núñez V.M., García-Martínez B.I., Rosado-Pérez J., Santiago-Osorio E., Pedraza-Chaverri J., Hernández-Abad V.J. Effect of 600 mg alpha-lipoic acid on oxidative stress, inflammation, and RAGE in older adults with type 2 diabetes. Oxidative Medicine and Cellular Longevity Article ID 3276958 (2019). doi:10.1155/2019/3276958
  • Ledesma-Martínez E., Aguiñiga-Sánchez I., Weiss-Steider B., Rivera-Martínez A.R., Santiago-Osorio E. Casein and casein-derived peptides as antileukaemic agents. Journal of Oncology Article ID 8150967 (2019). doi:10.1155/2019/8150967
  • Rosado-Pérez J., Aguiñiga-Sánchez I., Santiago-Osorio E., Mendoza-Núñez V.M. Effect of Sechium edule var. nigrum spinosum on oxidative stress and pro-inflammatory markers in older adults with metabolic syndrome: Exploratory study. Antioxidants 8(5):146 (2019). doi:10.3390/antiox8050146
  • Ledesma-Martínez E., Mendoza-Núñez V.M., Santiago-Osorio E. Mesenchymal stem cells for periodontal tissue regeneration in elderly patients. The Journals of Gerontology: Series A 74(9):1351–1358 (2019). doi:10.1093/gerona/gly227
  • Weiss-Steider B., Córdova Y., Aguiñiga-Sánchez I., Ledesma-Martínez E., Domínguez-Meléndez V., Santiago-Osorio E. Sodium caseinate and α-casein inhibit proliferation of mouse myeloid 32D cl3 cells via TNF-α. Biomédica 39(3) (2019). doi:10.7705/biomedica.v39i3.4094
  • Hernández-Monjaraz B., Santiago-Osorio E., Ledesma-Martínez E., Alcauter-Zavala A., Mendoza-Núñez V.M. Retrieval of a periodontally compromised tooth by allogeneic dental pulp MSC grafting: Case report. Journal of International Medical Research 46(7):2983–2993 (2018). doi:10.1177/0300060518773244
  • Mendoza-Núñez V.M., Arista-Ugalde T.L., Rosado-Pérez J., Ruiz-Ramos M., Santiago-Osorio E. Hypoglycemic and antioxidant effect of Tai Chi training in older adults with metabolic syndrome. Clinical Interventions in Aging 13:523 (2018). doi:10.2147/CIA.S157584
  • Suwalsky M., Castillo I., Sánchez-Eguía B., Gallardo M., Dukes N., Santiago-Osorio E., Aguiñiga I., Rivera-Martínez A. In vitro effects of benzimidazole/thioether–copper complexes with antitumor activity on human erythrocytes. Journal of Inorganic Biochemistry 178:87–93 (2018). doi:10.1016/j.jinorgbio.2017.10.009
  • Aguiñiga-Sánchez I., Cadena-Íñiguez J., Santiago-Osorio E., Gómez-García G., Mendoza-Núñez V.M., Rosado-Pérez J., Ruiz-Ramos M., Ledesma-Martínez E., Delgado-Bordonave A.J., Cisneros-Solano V.M., Soto-Hernández R.M. Chemical analyses and in vitro and in vivo toxicity of Sechium edule var. nigrum spinosum fruit methanol extract. Pharmaceutical Biology 55(1):1638–1645 (2017)
  • Salazar-Aguilar S., Ruiz-Posadas L.M., Cadena-Íñiguez J., Soto-Hernández M., Santiago-Osorio E., Aguiñiga-Sánchez I., Rivera-Martínez A., Aguirre-Medina F. Sechium edule: A new cultivar with antiproliferative potential in HeLa cells. Nutrients 9(8):798 (2017). doi:10.3390/nu9080798
  • Santiago-Osorio E., Ledesma-Martínez E., Aguiñiga-Sánchez I., Poblano-Pérez I., Weiss-Steider B., Montesinos-Montesinos J.J., Mora-García M. Sodium caseinate induces mobilization of hematopoietic stem cells in BALB/c mice. Medical Science Monitor Basic Research 21:206–212 (2015). doi:10.12659/MSMBR.895442
  • Aguiñiga-Sánchez I., Soto-Hernández M., Cadena-Íñiguez J., Ruíz-Posadas L., Cadena-Zamudio J., González-Ugarte A., Weiss-Steider B., Santiago-Osorio E. Sechium edule hybrid fruit extract induces apoptosis in leukemic cell lines but not in normal cells. Nutrition and Cancer 67(2):250–257 (2015). doi:10.1080/01635581.2015.989370
  • Córdova-Galaviz Y., Ledesma-Martínez E., Aguiñiga-Sánchez I., Soldevila-Melgarejo G., Soto-García I., Weiss-Steider B., Santiago-Osorio E. Sodium caseinate increases survival in a leukemic mouse J774 model (in vivo). In Vivo 28(5):819–825 (2014)
  • Luviano A., Aguiñiga-Sánchez I., Demare P., Tiburcio R., Ledesma-Martínez E., Santiago-Osorio E., Regla I. Antineoplastic activity of rinvanil and phenylacetylrinvanil in leukemia cell lines. Oncology Letters 7(5):1651–1656 (2014). doi:10.3892/ol.2014.1958
  • Ledesma-Martínez E., Pérez-Cordero C.L., Córdova-Galaviz Y., Sánchez-Téllez G., Huerta-Yépez S., Aguiñiga-Sánchez I., Miranda-Peralta E., Monroy-García A., Weiss-Steider B., Santiago-Osorio E. Casein induces apoptosis of WEHI-3 leukemic cells and increases survival in a mouse leukemia model. Oncology Letters 4(3):461–466 (2012). doi:10.3892/ol.2012.758
  • Domínguez-Meléndez V., Silvestre-Santana O., Moreno-Fierros L., Aguiñiga-Sánchez I., Martínez L., Marroquín-Segura R., Mora-García L., Santiago-Osorio E. Sodium caseinate induces mouse granulopoiesis. Inflammation Research 61(4):367–373 (2012). doi:10.1007/s00011-011-0421-7
  • Rodríguez-Solano L., Aguiñiga I., López-Ortiz M., Tiburcio R., Luviano A., Regla I., Castillo I. Bis(2-methylbenzimidazolyl)amine-derived copper complexes and their antineoplastic activity. European Journal of Inorganic Chemistry 2011(23):3454–3460 (2011). doi:10.1002/ejic.201100301
  • Santiago-Osorio E., Mora L., Bautista M., Montesinos J., Martínez I., Ramos G., Zambrano R., Monroy A., Weiss B., Ledesma E. Sodium caseinate induces secretion of M-CSF from neutrophils. Immunobiology 215:332–339 (2010). doi:10.1016/j.imbio.2009.03.003
  • Santiago-Osorio E. Alpha, beta, and kappa caseins inhibit proliferation of 32D cl3 and WEHI-3 myeloid cell lines and show distinct differentiation properties. Immunobiology 213:133–141 (2008). doi:10.1016/j.imbio.2007.07.004

Additional Indexed Publications

  • Soto-Hernández R.M., Ruiz-Posadas L.M., Aguiñiga-Sánchez I., Santiago-Osorio E., Arévalo-Galarza M.L., Avendaño-Arrazate C.H., Cisneros-Solano V.M., Cadena-Íñiguez J. Use of Mexican chayotes for diseases of public interest. Agroproductividad (Suppl.):51–53 (2016)
  • Cadena-Íñiguez J., Soto-Hernández M., Torres-Salas A., Aguiñiga I., Ruiz-Posadas L., Rivera-Martínez A., Avendaño-Arrazate C., Santiago-Osorio E. Antiproliferative effect of chayote varieties on tumor cell lines. Journal of Medicinal Plants Research 7(8):455–460 (2013). doi:10.5897/JMPR12.866
  • Santiago-Osorio E., Ledesma-Martínez E., Weiss-Steider B., Muñoz-Galindo L., Domínguez-Meléndez V., Aguiñiga-Sánchez I., Córdova-Galaviz Y., Moreno-Fierros L., Tiburcio-Félix R. Advances in regulation of proliferation and differentiation of normal and leukemic hematopoietic cells by casein and its components. Revista de Hematología 11(4):193–198 (2010)
  • Ledesma-Martínez E., Pérez-Cordero C.L., Sánchez-Téllez G., Aguiñiga-Sánchez I., Córdova-Galaviz Y., Weiss-Steider B., Santiago-Osorio E. Differential modulation by sodium caseinate of proliferation/viability in WEHI-3 leukemic cells, normal hematopoietic cells, and co-culture. Vertientes 16(1):5–8 (2013)