Modesto Gómez López, Ph.D.

Specialty: Molecular biology, electrical bioimpedance biosensors, oxidative stress & inflammation, clinical/translational research in metabolic, neurologic and infectious diseases

Dr. Modesto Gómez López is a molecular biologist whose work spans label-free electrical bioimpedance (EBIS) biosensing, gene expression and epigenetics, and clinical/translational studies in type 2 diabetes, obesity, fibromyalgia, COVID-19/post-COVID, oral/periodontal health, infertility genetics and neurodegeneration. His output includes peer-reviewed articles, conference proceedings, and funded projects integrating bench methods with clinical endpoints.

SNI: National Researcher (SNI) Level I

Areas of Expertise

• Label-free electrical bioimpedance (EBIS) biosensors; PCR product detection; QCM-D assays
• Gene expression, DNA methylation, and polymorphisms (e.g., OGG1 Ser326Cys)
• Oxidative stress, redox-inflammation markers, and metabolic disease (T2D, obesity)
• Oral/periodontal research, oral microbiome & candidiasis; orthodontics-related oxidative stress
• Hyperbaric oxygen therapy and post-COVID-19 clinical markers; neurodegeneration models

Education

• Ph.D. in Medical Research (Molecular Biology) — Escuela Superior de Medicina, Instituto Politécnico Nacional (2015)
• M.Sc. in Health Sciences (Molecular Biology) — Escuela Superior de Medicina, Instituto Politécnico Nacional (2011)
• B.Sc. in Biology — Universidad Michoacana de San Nicolás de Hidalgo (2004)
• Postdoctoral Fellowship — Malnutrition & Flow Cytometry Program, UAM-Iztapalapa (2017)

Funded Projects

• Neurodegeneration in glaucoma and oral-bacteria–driven inflammation in patients with diabetes mellitus (Basic Science Call 2016)
• Regulation of oxidative stress and inflammation in diabetic foot patients treated with hyperbaric oxygen (SIP: 20181822)
• Magnetically anchored geno-sensor with electrical bioimpedance measurements (SIP: 20182372)
• Cognitive-behavioral/psychophysiological intervention for gene-expression modulation in fibromyalgia (SIP: 20196188)

Conferences & Academic Contributions

• Polymorphisms (OGG1 Ser326Cys) and 8-OHdG in infertile men (2024)
• Cytokine genetics in post-COVID-19 patients (2024)
• REST and NRF2 expression in late-onset Alzheimer’s disease (2019)
• NLRP10 inflammasome/ET-1 expression in systemic sclerosis (2019)
• Chronic periodontitis with T2D: cytokines and MMPs (2018)
• Periodontitis progression markers in T2D; FCQ validation; TLR-4/AMPK/OPG/CAV-1 expression (2017)

Scientific Publications

2025

1. Arias-González L., Cruz-Ramos J.A., Pérez-Vielma N.M., Munguía-Cervantes J.E., Hernández-Sánchez E., Rojas López M., Gómez López M. Correlation of EBIS vs. concentration and purity of total DNA in breast cancer samples. Journal of Physics: Conference Series 3014:012011 (2025).
2. Pérez-Vielma N.M., Aguilera-Sosa V.R., Betancourt Méndez E., Sánchez-Camacho J.V., Andrade-Torres C.M., Gómez López M. Food craving, stress and depression during COVID-19 confinement in university students. Revista Mexicana de Trastornos Alimenticios 15(2) (2025). doi:10.22201/fesi.20071523e.2025.2.811
3. Cabrera Catalán B., Cleva-Villanueva G., Pérez-Vielma N.M., Lara-Padilla E., Romero-López E., Herrera-López M.E., Camberos-Schiaffini D.D., Gómez López M. Use of bioimpedance as an early diagnostic tool in diabetes. Journal of Physics: Conference Series 3014:012003 (2025). doi:10.1088/1742-6596/3014/1/012003
4. Valencia-Gutiérrez M.M., Gómez-López M., Pérez-Vielma N.M., Lázaro-Aguilar P., Aguilera-Sosa V.R. Clinical characteristics and cytokine gene expression in post-COVID-19 syndrome. Rev Med Inst Mex Seguro Soc 63(1):e6501 (2025).

2024

5. Bandala C., Carro-Rodríguez J., Cárdenas-Rodríguez N., Peña-Montero I., Gómez López M., et al. Comparative effects of Gymnema sylvestre and berberine on adipokines, body composition and metabolic parameters in obesity: Randomized study. Nutrients 16:2284 (2024). doi:10.3390/nu16142284
6. Pérez-Vielma N.M., Valencia-Gutiérrez M.M., Sánchez-Camacho J.V., González-Hernández J.E., Miliar-García Á., Ochoa C., Labovitz J., Gómez-López M. Hyperbaric oxygen therapy reduces oxidative stress and inflammation in diabetic foot ulcers: Preliminary study. Heliyon 10:e40586 (2024). doi:10.1016/j.heliyon.2024.e40586
7. Sánchez-Camacho J.V., Gómez-Chavarín M., Galindo-Solano N., Padilla-Cortés P., Maldonado-García J.L., Pérez-Sánchez G., Pavón L., Ramírez-Santos J., Roldán Roldán G., Gómez-López M., Gutierrez-Ospina G. Nano-PSO benefits in rotenone “Parkinsonian” rats revealed by non-categorical analyses. Int J Mol Sci 25:12635 (2024). doi:10.3390/ijms252312635
8. González-Díaz C.A., Suárez-Souto M.A., Pérez-Soto E., Gómez-López M., et al. OGG1 Ser326Cys polymorphism in infertile men. Biomedicines 12:2286 (2024). doi:10.3390/biomedicines12102286
9. Morán-Guel E., Gómez-López M., Delgado-Aguirre H.A. Risk factors for hospital-acquired infection in COVID-19. Med Crit 38(3):162–168 (2024). doi:10.35366/117778
10. Pérez-Vielma N.M., Gómez-López M., Martínez-Godínez M.A., Luna-Torres A.L., Domínguez-López A., Miliar-García Á. Candida variety in the oral cavity of Mexican subjects with type 2 diabetes and TLR2 expression. Clin Pract 14:417–425 (2024). doi:10.3390/clinpract14020031

2023

11. Pérez-Vielma N.M., Gómez-López M., Maldonado-Vázquez J., Correa-Basurto J., Martínez-Godínez M.A., Miliar-García Á. Interaction of peptide Val-Pro-Pro with minimal promoter regions of SOD/CAT: QCM-D and docking. Analytical Methods (2023).
12. Padilla-García K.L., Gómez López M., Sánchez-Camacho J.V., Andrade-Torres C.M., Pérez-Vielma N.M., González-Díaz C.A. Bioimpedance spectra in final RT-PCR products: Sensitivity threshold analysis. CNIB Proceedings 2022.2023:665–673 (2023).
13. Ángeles-Estrada L., Pérez-Soto E., Pérez-Vielma N.M., Gómez-López M., Sánchez-Monroy V. Oxidative stress and genotoxicity in oral epithelial cells with fixed orthodontic appliances. Clinical Oral Investigations (2023).
14. Hernández-Rodríguez J., Herrera-López M.E., Montiel-Flores E., Romero-Morelos P., Bandala C., Gómez-López M., et al. Young university students. Investigación en Discapacidad 9(2):65–74 (2023).
15. Carrizalez-Luna J.E., Reséndiz-Albor A.A., Arciniega-Martínez I.M., Gómez López M., Campos-Rodríguez R., Pacheco-Yépez J.C., Drago-Serrano M.E. Nicotinic modulation and intestinal IgA response markers. Biomedical Reports 13 (2023).
16. Rojas-Ortega D.A., Rojas-Hernández S., Sánchez-Mendoza M.E., Gómez-López M., Sánchez-Camacho J.V., Rosales-Cruz E., Carrasco-Yépez M.M. Role of FcγRIII in nasal cavity of BALB/c mice in primary amebic meningoencephalitis protection. Parasitology Research (2023). doi:10.1007/s00436-023-07810-w

2022

17. Morales-Magaña J., Arciniega-Martínez I.M., Drago-Serrano M.E., Reséndiz-Albor A.A., Jarillo-Luna R.A., Cruz-Baquero A., Gómez-López M., Guzmán-Mejía F., Pacheco-Yépez J. Cholecystokinin outcome on intestinal IgA response markers. 2022.
18. Bioimpedance spectra in final RT-PCR products: Sensitivity threshold analysis. 2022.

2021

19. Ames-Lastra G., Castillo-Salazar I.A., Hernández-Nava A., Sánchez V., Gómez-López M., Pérez-Vielma N., González-Díaz C.A. DNA biosensor via relative bioimpedance and genetic amplification: Preliminary results. Journal of Physics (2021).
20. Ames-Lastra G., Sánchez V., Sacristán-Rock E., Gómez-López M., Pérez-Vielma N., Castillo-Salazar I.A., Hernández-Nava A., González-Díaz C.A. Bioimpedance spectroscopy as a label-free technique to detect PCR products. Journal of Physics (2021).
21. Hernández A., Ames-Lastra G., Sánchez V., Gómez M., Sánchez J., Pérez-Vielma N.M., Castillo I.A., González C.A. Correlation between DNA concentration and electrical bioimpedance. Journal of Physics (2021).
22. Pérez-Vielma N.M., Miliar-García Á., Gómez López M., Marín-Soto M.D., Leija-Alva G., Aguilera-Sosa V.R. Food craving in obese subjects: Correlation with atherogenic index and gene expression. Acta de Investigación Psicológica (2021).
23. Marín-Soto M.D., Miliar-García Á., Gómez-López M., González-Mundo I., Aguilera-Sosa V.R. Association between food craving and taste genes in obesity. Investigación Clínica 62(2):119–131 (2021). doi:10.22209/IC.v62n2a03
24. Sandoval-Valerio A.K., Aguilera-Sosa V.R., Miliar-García Á., Gómez López M., et al. Catastrophic thinking, pain and inflammation in fibromyalgia: From behavior to molecular biology. Investigación Clínica 62(2):140–158 (2021). doi:10.22209/IC.v62n2a05

2020

25. González-Mundo I., Pérez-Vielma N.M., Gómez-López M., et al. REST DNA methylation in PBMCs and antioxidant enzyme gene expression in late-onset Alzheimer’s disease. Experimental Gerontology 136:110951 (2020). doi:10.1016/j.exger.2020.110951
26. Gómez-López M., Miliar-García Á., Pérez-Vielma N.M., Lara-Padilla E., et al. Biosensor of inflammation biomarkers using electrical bioimpedance on immobilized DNA (no chemical modification). J Electr Bioimp 11:31–37 (2020). doi:10.2478/joeb-2020-0006
27. Gómez-López M., Miliar-García Á., Pérez-Vielma N.M., Ames-Lastra G., Lara-Padilla E., Chávez K.V., García A.R., Delgado J., Cortés E., González-Díaz C.A. Biosensor of inflammation biomarker NLRP3 based on electrical bioimpedance. IFMBE Proceedings 75:1488–1493 (2020). doi:10.1007/978-3-030-30648-9_191
28. Sandoval-Valerio A.K., Pérez-Vielma N.M., Miliar-García Á., Gómez-López M., et al. Negative thoughts, stress and 5-HT1A receptor in women with fibromyalgia. Acta de Investigación Psicológica 10(3) (2020). doi:10.22201/fpsi.20074719e.2020.3.3619

2019

29. Joseph E., Villalobos-Acosta D.M.A., Torres-Ramos M.A., Farfán-García E.D., Gómez-López M., et al. Neuroprotective effects of apocynin and galantamine in a scopolamine Alzheimer model. J Mol Neurosci (2019). doi:10.1007/s12031-019-01426-5
30. Gómez-López M., Miliar-García Á., Pérez-Vielma N.M., Ames-Lastra G., Lara-Padilla E., Chávez K.V., et al. Biosensor of inflammation biomarker NLRP3 based on electrical bioimpedance. IFMBE Proceedings (2019).
31. Cabrera-Pérez L.C., Padilla-Martínez I.I., Cruz A., Correa-Basurto J., Miliar-García Á., Hernández-Zavala A.A., Gómez López M., Rosales-Hernández M.C. Benzothiazole derivatives as 11β-HSD1 inhibitors: Design, docking and in vitro evaluation. (2019).
32. Bandala C., Ávila-Luna A., Gómez-López M., et al. Catecholamine levels and receptor gene expression in osteosarcoma tissues. Arch Physiol Biochem (2019). doi:10.1080/13813455.2019.1638942
33. Gómez López M., Pérez-Vielma N.M., González-Martínez H., Lara-Padilla E., Bandala C., González-Torres M.C., Miliar-García Á. NLRP3, IL-1β and Caspase-1 transcripts by QCM-D in obese children. Journal of Sensors (2019). doi:10.1155/2019/4323056

2018–2017

34. Hernández-Uribe C., Gómez López M., Pérez-Vielma N.M., González-Hernández J.E., Miliar-García Á. Cytokines and MMPs in chronic periodontitis with type 2 diabetes (Mexican population). Journal of Bioengineering and Biomedicine Research (2018). (Extended proceedings)
35. Cadena-Gordillo K.E., Castro-Molina G.A., Miranda-Ruiz M., Sosa-Gómez A., Pablo-Velázquez A.M., Pérez-Vielma N.M., Martínez-Godínez M.A., Domínguez-López A., Gómez López M., Miliar-García Á. Oral candidiasis in DM2 patients and oral health status. (2018). (Extended proceedings)
36. Gómez-Conde E., Díaz-Orea M.A., Pimentel-Morales A., Cárdenas-Perea M.E., Galicia-Zamalloa A.L., Guerrero-González T., González-Barrios J.A., Gómez-López M., Lara-Padilla E. MAP4/MAP6 expression in breast-cancer cell lines. Int J Clin Exp Pathol 10(6):7017–7022 (2017).
37. Chávez-Baldenebro K.V., García-Sánchez A.R., Gómez López M., Pérez-Vielma N., Delgado J., Cortés E., González-Díaz C.A. Complementary DNA biosensor via electrical bioimpedance spectroscopy. COMIB/CNIB (2017). dx.doi.org/10.24254/CNIB.17.93